Unable to delete thumbs.db

I'm on the newest Win10 and am looking for a way to delete folders which only contain one file, the thumbs.db, and nothing else.

I've read several things in this thread (which is now closed) where some didn't help and others were too painful to be even tried (why should i have to boot in safe mode?).

Is there a easy way to delete those folders?

I'm often succeeding with restarting explorer.exe from the taskmanager's app tab (wondering why explorer.exe is the only process offering "restart" in its context menu) and then being quick enough to delete such folders before explorer grabs em again. But there are always some hard ones which somehow escape this hack.

For such the only working thing i know of is to actually end all explorer.exe processes, delete the folder from a cmd line with rmdir /S/Q "foldername" and restart explorer.exe. But both approaches are a pain because usually i have many explorer.exe windows open an don't like to restore them all manually because that's a waste of time.

Is there a proper way to delete those folders which doesn't involve hacking the registry, changing system wide settings, booting from a linux live cd or killing explorer.exe? After all their empty so i don't understand why there's the need to hold on to a thumbs.db which by then shouldn't contain any thumbs. Maybe there's a purge-unused-thumbs option somewhere?