Hey, the same issue. Not sure when it actually started. First I thought it my software problem because at the start it usually happend only in Illustrator. But just take charge or put it resolving this issue. After it started just when I open my laptop, I decided just delete Illustrator because it was annoying. It doesn't help and I thought I've got a virus. Tried 3 antivirus: Nod32, Bitdeffender and Avast, non of them didn't find any problem.
So I just reinstalled system and wished it not gonna happens again. But as appears problem not in the software, just in the windows. Because if that happens I can move cursor by mouse and touchpad but nothing react on my left click. Actually found one interesting thing, when it happens my right click still working only on the desktop(main window of windows). And only there.
Right now me helping just ctrl+alt+del and back to the windows without any sign out or task bar.
And actually when that's happens I can open taskbar through ctrl+shift+esc, but again it doesn't respond on any click while showing all information and application in the real time.
SO MICROSOFT, PLEASE PAY YOUR ATTENTION!!!