Have you figured out how to fix this?
I have Gigabyte B550 DS3H and am having what sounds like the exact same issue. I used to happen randomly but now happens every time it goes to sleep. The mouse and keyboard don't wake it from sleep. Plugging in USB or unplugging USB devices doesn't work. Fans are spinning full speed and RGB is all lit up like my PC is working hard. The power/reset button is also unresponsive so the only way to fix is to turn off the PSU.
Solutions I've tried:
Bios and Drivers Updates
Windows update
Windows reinstall
Fast boot disabled
Hybrid sleep disabled
Away Mode disabled