We have been chasing this problem for quite a while. I suggest creating a restore point once you get your computer working, but yes we have had to re-install on many occasions.
We have had this problem on every brand of computer, so it's not a Dell or Asus problem, it's deffinately a windows issue.
I removed a group policy which prevented apps from running under AppData and it appeared to work for a while, but then the issue propped up again.
Would love some help from MS on this.