We have had loads of machines update with the 2004 update and nearly all are OK. Had one yesterday the really misbehaved itself. (Dell Optiplex 3070, 8GB RAM, 256GB SSD.)
Once started the system would work ok for about a minute and then things got very slow. I Tried all of the above, nothing worked. I tried rolling back updates and features, this couldn't be done.
I uninstalled MS Office and Antivirus , OneDrive, etc etc and took everything off to bare Windows10, still the same: very slow:
Eventually, the machine gave up and wouldn't start properly and booted straight into the Trouble Shooting menu, I tried the usual, Startup repair etc, Wouldn't work.
I had no option but to Reset Windows10. When I did this the machine was definitely alot faster, but I still wasn't happy with it, there was something not right, so I removed it from the domain, and deleted the existing user profile, downloaded and ran the 2004 update, rejoined the domain, reinstalled all programs and now it feels like a good solid installation again.
In this instance the 2004 caved the machine:
In my opinion from a general user viewpoint , never disable the SysMain service and the indexing service.
With all of the computers we have updated with the 2004 update, to only have ONE go bad so far, this is not a bad record.
So, if you have this issue, the most time cost effective way to sort it is to do a REFRESH install, (Keeping personal files only). This way you will be confident that the job is a good one!