My bigger concern there would be using SMBv1. Any port in a storm, I guess. Speaking of which...
This should be solvable/avoidable/workaroundable for OneDrive for Business users by redirecting folders into %OneDriveCommercial% (or a subfolder thereof). That can be done by the usual Folder Redirection GPO, or if Documents, Desktop & Pictures are all you care about, by the OneDrive GPO. Then no Offline Files are involved (at least for Known Folders). Discussion about that here: https://answers.microsoft.com/en-us/msoffice/forum/msoffice_onedrivefb-mso_win10-mso_o365b/odfb-known-folders-vs-group-policy-folder/db89d0a5-e02b-4fe4-9432-c86404d70003
If you're going that direction anyway (I am at one 2004/Offline Files-afflicted client that also wants to do away with their file server), this might be the time. Might need to follow it up with one, last Offline Files cache reset, or else disable the service by GPO.
Since we don't know how long it will take Microsoft to fix it since they haven't even published that the bug exists, expect it to take a while. (Well, I think we're already beyond "a while"!) Therefore, I'm also toying with using this for other sites that have no plans to eliminate their file server but use ODfB.