Flight Sim 2020 keeps crashing even with the a beast of a PC and Video card?

Try restarting your pc, update the driver cause my driver have a update only for MFS2020 and after I update it, I just reinstall the game and it work and only crash once for me I play in high end setting.

Not really, that is not true for everyone, the coding on this game is so finicky and broken, i've gone through a hundred steps, and the game just crashes intermittently , sometimes I get 10 minutes sometimes 25 , sometimes crashes at 3 minutes. Removing all my overclocking has not changed the end result , either has the developers "suggestions" I've never seen a game launched that the dev's ask you to run your computer with everything off just to make it work. Absolutely asinine

I figured out the solution. This applies only if you have over clocked computer components. Start by undoing any memory (RAM) over clocks. If that does not work, try undoing GPU over clocks followed by CPU over clocks. Undoing ram over clocks fixed it for me. I was at 3300 MHz when I had to revert back to 3200 MHz.

At first, I have the very same problem but when u reinstall the game after updating my pc and the driver, it seem to be working smoother now but still crash here and there.

Somewhat guiltily (I'm a refugee from X-Plane 11), I purchased the top MS Flight Simulator 2020 package, and because of the hype - I was expecting wonders which should not be missed!

However, over several days my fairly beefy Windows 10 system froze numerous times with screens of various colours whilst I tried to download the new simulator, then when trying to install it, and then when trying to run it.  However, I seemed to be progressing slowly, and my system was within spec, and I had of course done all the recommended OS and driver updating, so ultimately there was no reason for it not to work.  So I persevered. 

Then maybe all those hardware resets were just too much for the system, because the motherboard just gave up the ghost.  Maybe too much strain, and no way for the poor motherboard to complain to me what I was putting it through, other than by putting an end to its own misery.

Luckily the local computer store had in stock a ASRock x570 Steel Legend, a Ryzen 5 2600 processor and 32GB of memory to suit.  Not the top end, and reasonable at AUD $805 (that would be USD $578 to you guys).

I was confident now that I could now run Flight Simulator from its own dedicated SSD (drive E:) without problems.  But no!  Blank screens of various colours at different times.  Have not managed a flight yet.  Mere crash to desktop would be nice compared with the frozen screen!  You're lucky guys!

PS.  The furthest I got with the application was when I opened it through GeForce Experience.  This is "a companion application to your GeForce GTX graphics card keeping it up to date and optimising your game settings etc. etc.".  Strangely, it lists the games on the machine and allows you to run them through the app.  I got into the various controls, cameras etc. but the controls didn't actually work this time (they did work once previously).