No, Event ID 455 errors don't cause "access denied" errors.
(1) What application are you running that occasionally produces them?
(2) Can you right-click the app, & select "run as administrator"?
(3) If (2) works to stop the access denied errors, run it from a shortcut...
(a) Right-click the app in File Explorer, point to "Send to",
& select "Desktop (create shortcut)"

(b) Right-click the shortcut on the Desktop, & select Properties.
(c) At the Shortcut tab, click the Advanced button.
(d) Put a checkmark into "Run as administrator".

Now when you run it using that shortcut, it will be an Administrator.
Mr. Asmussen stated his issue was not being able to find
C: \Windows\system32\config\systemprofile\AppData\Local\
So he could make the directory 'TileDataLayer/Database'. More than one reply answered the procedure to resolve his problem.
Someone else had an issue making the directory and got an 'Access Denied'.
Your answer has absolutely nothing to do with the question at hand or issues related to resolving the question.
Making a shortcut with administrative privilege has nothing to do with an 'Access Denied' error occuring when creating a directory that requires administrative privileges.
If it's me that has misinterpreted the question at hand, then I apologise. But, I've read the original question over again and subsequent issues associated with the resolve. I think I'm correct in saying the above reply, even though correct in procedure,
does not belong here.