I had the exact same problem with this new Windows build - ntoskrnl.exe was spiking badly at about 6000µs which caused really bad audio dropouts even when simply listening to music in winamp.
After reading the whole thread I went on and installed the newest update (KB4505903) which almost solved the problem, ntoskrnl was not spiking anymore, but instead some nvidia driver component was, I believe it was dxgkrnl.exe (at the time I had installed nvidia 431.36 driver in my system).
After installing the latest 431.60 driver the problem COMPLETELY went away. So there you go, maybe this will help out someone out-there.