I've been watching this issue for a while. I admit that I don't always read the responses, so I may need to follow the threads. Honestly , I picked yours at random thinking that you may see something with my experience.
I had a problem with my Epson 750 under windows 7 enterprise after a Windows update. I'd need to dig through emails to see if I logged it. My guess was that it was the registry. My PC would not recognize the scanner at all.
I initially installed the scanner Feb 2007 under Windows XP. I installed the scanner on it's current home under win 7 enterprise in September 2009. Sometime around July- August 2018 I started having issues after an update.
Removing the update didn't help.
Epson didn't help.
reinstalling the Epson software didn't help.
Running all the scans against windows 7 didn't help.
There was also a third party software ( I think it was vuescan) that I tried and it didn't work either. Their tech support said that it didn't rely on the Epson drivers.
At that point, my last option was to reinstall the OS, so if I had to reinstall I figured I might as well install Windows 10 since the scanner worked on my laptop with windows 10.
It's been working since Sept 2018 under windows 10.
It is currently running under Win 10 Pro 1909 with all current updates.