Here's a fix for the disappearing window problem:
http://www.geekstogo.com/forum/topic/291186-epson-scan-utility-wont-work/page__view__findpost__p****
It involves going into the registry and deleting the saved Environment for Epson Scan. On my machine this was: Computer\HKEY_CURRENT_USER\Software\EPSON\EPSON Scan\ES013D\Environment
It's mind boggling that something like this that should have a simple fix is still an issue.
Yes, brilliant!! That fixed the problem. Ugh! Took so long to identify that the pop-up interface was off the screen. I thought it was something else and spent a lot of time identifying what that something else is.
Bookmarked this fix!