I experience the same problem with my Epson V330 scanner in Windows 10 - if I change focus to another window, Epson Scan freezes when I try to return. Then I have to end the task in Task Manager and replug the USB interface.
I have not tried any of the suggestions offered here, but I find that I can still use Epson Scan if I am careful. Here is what I do.
- If I switch to another application, e.g. by clicking in another window, I can return to Epson Scan by clicking either the Scan button or the Preview button, and not anywhere else in the Epson Scan window. Epson Scan then continues to work.
- I never minimize the Epson Scan window. Rather than do that I close and restart it when I are ready to return.
This isn't a fix but a limp-along. It works for me, so I offer it here.