Same here, come after i close game.
I have 4k monitor too, . After exiting a lower resolution game (fullscreen DOSbox for instance) some of the icons are out of sight and can't be interacted with until I restart the explorer process
Doubt it would matter, but the desktop (1440p) is running a gtx 970, and the laptop (1080p) is using integrated intel gfx for desktop and an nvidia mx150 maxq for most games (optimus)