My original post above was written before I took the time to research and find the article which I later added via edit. Since I didn't have time at that point, I simply added that article URL without correcting how this might affect the original post.
The key information here relates to the new 'high-severity' exploit discovered by Google back in November and disclosed in late February once the 90-day and 14-day grace periods had passed. Here's another article that provides a better synopsis and doesn't confuse the situation by including an unrelated set of exploits discovered and patched in February 2017.
Windows 10 security Google exposes how malicious sites can exploit Microsoft Edge
This is exactly the type of potential Edge vulnerability I'd guessed might exist based on what we've learned in this thread, while the common attack vector of the ad networks (e.g. Malvertising) is relatively unimportant, except as the possible workaround it might provide for those with the knowledge and initiative to proactively protect themselves in the future. The utter futility of attempting to manage this avenue of attack itself is well known in the security community and has only minimal relation to the website being visited when such attacks occur, since the ads are often operated in a "pass-through" manner.
What's more important to note here, is that if as I've guessed the Trojan:JS/Flafisi.D and it's family of detections are indeed related to this 'ACG bypass using UnmapViewOfFile' vulnerability in Microsoft Edge, then the core issue will likely be resolved once Microsoft releases their update, tentatively planned for this coming Black Tuesday March 13th.
Since the dates the various Trojan:JS/Flafisi family detections were originally released began in early December 2017 and continue into mid-February, this seems a reasonable guess.
So though as anyone who's ever installed an ad-blocker (or simply enabled the Tracking Protection and added an appropriate tracking list in Internet Explorer 11) already knows, their own encounters with malvertising attacks are minimal, for most this current burst of detections is likely to dissipate over the next few weeks.
Like any such newly identified zero-day vulnerability, the incidence of attacks has merely spiked ahead of the release of the update and will of course be added into the malware 'kits' in the future, as another potentially unpatched vulnerability. Nothing really new here except the vulnerability itself.
Rob