I also have this problem, 100% disk usage constantly.
Disabled Superfetch
Disabled Windows Search
Was working fine for 1 - 2 days then suddenly after my PC had been on for about 3 hours it just spikes back to 100% and i need to then go into MSC and start the above services and then disable them again to fix the problem.
Please note i have had this PC for 1 year. Only in august did this start becoming a problem. Windows 10 is utter garbage and i wish they didn't force people to pay £150 to get Windows 7 installed when you buy a new PC. This is as bad as apple forcing their crappy software/hardware on ALL users and making things incompatable with 3rd party items is the stupidest thing that any company could ever do.