Actually, this problem has happened to my work laptop 4 times since July 31. The most recent deletions was twice today. Each time it creates a new profile, 000, 0001,0002, etc. It leaves the folder structure intact, but deletes the contents of all the folders.
My stuff was actually safe in the previous folder but before I had time to copy my things, a couple of hours later, it created yet another profile. This time, everything went - contents of desktop, docs, photos, videos. and all preferences, but folder structure is still there.
My stuff is always backed up to a portable drive and I only leave stuff on my desktop that I can afford to lose, but I'm getting tired of re-syncing my bookmarks and other customizations such as wall papers and power schemes.
For the record, I'm on 1809 Microsoft Windows [Version 10.0.17134.376] Surface Book.
Frankly, I'm the only one in my organization with the problem (that I know of) so tomorrow, I'm just going to image it and start over and hope a fresh copy of Windows will make the problem go away.