What's going on is exactly what the notification from CFA told you, the applications involved are attempting to make some sort of change in the Windows Desktop folder of the user starting the program.
The problem with this is that it's the same type of operations that might be seen when a ransomware attack attempts to modify items in the Desktop Folder in order to make your system non-functional or encrypt whatever personal files you may have placed there.
The decision you (and the developers of those badly behaving programs) need to make is whether the actions being attempted by these otherwise valid programs truly need to occur, since these are why Microsoft can't simply block all access to folders like the Desktop in order to avoid ransomware attacks altogether.
Since the most common reason that older (e.g. outdated design) applications made such access to the Desktop was simply to add an icon, which is something you could do yourself with a simple set of mouse clicks. By automating this in either their installation programs or worse yet when you're simply starting the program itself, they create issues for Microsoft when trying to protect you from programs with more malicious intent.
If all you see when using these programs is such notifications and they otherwise seem to operate properly, then you can simply ignore the message(s) and continue using the programs with CFA fully intact. If they don't work properly, then you'll need to allow those programs the rights within CFA to make changes to those folders or better yet, update to more current versions of these programs that no longer require this access.
In short, it's your trashy outdated software that's making it impossible for Microsoft to easily protect you from ransomware, so either get rid of them or live with it.
Rob