I'm also on an ASUS, specifically a P8P67 PRO Rev 3.1
Asus claims its not supported for Windows 10, but it worked fine until this recent update. I have just tried updating the BIOS, and will report back on if that does anything.
And... it didn't help. May have made things worse, in that one freeze completely screwed up the boot procedure. I had to go in and pull the BIOS battery to get it to reset, and then it booted again.
Well, as a third update, I did a complete Windows 10 clean install...
...and after two days of testing, I have not had a crash. It appears to have worked.