I am having the same issue. Card worked fine until I re-installed my windows, now it has a red x and says cannot start.
I have an AMD 8350 CPU, 16 Gigs of RAM, 500 Gig SSD, and R9 290 Video card.
Went to ASUS and have tried the latest version and the older version they offer. Same issue with windows, that is using the current ISO download from MS.