Hi Julie - thanks for the response - I have tried all the other steps in this thread, via powershell etc. I currently do not have a USB key so haven't been able to try running it on start up (however do believe this would work). Prior to my issues windows did dectect a trojan and Malwarebytes also picked up suspect registry keys and other PUPs.
I am thinking of doing a PC Refresh as there still seem to be small issues and my last windows 10 update did not run sucessfully - I am trying this first:
https://www.microsoft.com/en-us/wdsi/products/scanner#
Windows security scanner - however have had issues downloading the file as of now - the download is continually interupted/does not complete.