Am on macos sierra 10.12.1 running on 2011 iMac 27".
After os upgrade, my intellipoint mouse lost buttons 4 and 5 functionality.
The csrutil disable in safe boot method worked for me but after restart I had to unplug usb mouse and plug it back in the computer usb port and no the keyboard usb port.
Now buttons 4 and 5 are back as before.