Hi,
I've just solved this problem on my Dell Optiplex 990, running Windows 10.
It was running in RAID mode (as set in the BIOS) using iaStorAV.sys, and after an update from a hard drive to an SSD it was using often crashing with 100% of disk usage, but with no real activity (0 MB/s).
Having tried so many of the proposed solutions on the 'net (Virtual memory, disabling an interrupt, Windows Defender disable, Skype/Chrome mis-match), I finally went for changing the BIOS mode from RAID to AHCI. This forced a change of the driver to iaStor.sys instead of iaStorAV.sys and all the problems have gone.
So it does seem as though iaStorAV.sys has a problem, at least in Windows 10 with an SSD.
Note that in order to change from RAID to AHCI in the BIOS requires doing it whilst 'in' Safe Mode - as detailed here:
I hope this helps to solve someone else's problem - if only to point in the right direction (bad driver!).
Richard