If you look at my posts from 2015, here is what I experienced.
I had the Intel 4400 graphics card, which Microsoft told me would not work, so I purchased from Best Buy a AMD R7 240 and used the Amazon price, and the program still did not work. I called Microsoft again and after she checked out my computer, she transferred me to another department and during the transfer the system cut me out. Finally on the third call, I got a tech that was able to solve the problem using a scan program that is part of the Windows system.
My suggestion is if you want the Microsoft Flight Simulator X program to work with Windows 10, is to call Microsoft Support (I had used the call back feature, which my calls were returned 5 hours later) and give them my case number which was 1299988518 which should tell the technician that you contact how they fixed my problem.