Mouse and keyboard input not working after windows 10 upgrade from windows 7.

Very interesting addition to this problem.  Our laptop that has the same exact login profile is having the same issue.  It is a windows 8 machine.  The keyboard won't work but the mouse works fine.  It is an HP Envy, so the keyboard technically is not completely independent from the computer.

Same no joy with Logitech wireless keyboard/mouse and upgrade to Win 10 on Asus motherboard.   I tried all the above fixes including changing usb settings in bios and the best I could do is get into Win 10 after about 7 upgrades and roll backs once.   Then overnight when it went to sleep no joy again.

The most expeditious (saving time and spending less than $60) I have ordered a replacement Microsoft wireless keyboard/mouse combo.   I don't want to waste the time some of our colleagues have spent on this issue.   Remember when we upgraded to Win 7 and again when we updated to Win 8?   Both times it was months before Logitech could come up with a working device driver for the new OS.   Whether Microsoft is inserting malware to keep Logitech drivers from working or Logitech is simply woefully behind in building new drivers, doesn't matter.   Fact is the user gets the problem.   My new keyboard/mouse will be here tomorrow and I can forget this problem and go play golf today. 

I will keep the Logitech equipment and reinstall it in several months when the new drivers are ready.

I have run into the same issue as well.  After upgrading from Windows 7 to Windows 10, everything worked perfectly fine.  After Windows 10 came up I got a couple notifications of new drivers that needed to be installed for my GPU and my Razer Synapse program (using Razer USB keyboard and Razer USB mouse).  Like usual, after those types of driver updates the computer wants to restart.  So, I restarted the computer and now neither my keyboard or mouse work.  I have tried other USB ports with no successful results and have tried other USB keyboards and mice and my computer doesn't even register that they exist.

I don't have a way to remote access my computer from another computer and I don't have any keyboards or mice that aren't USB.  I would restore back to WIndows 7 but I have no way to control my computer.  I have tried multiple restarts as well with no success.

When I restart or turn on the computer the keyboard and mouse flash on for just a split second before going off and then my motherboard beeps at me and says there is no keyboard detected.

I really have no idea what to do at this point...maybe it's time to just buy a new SSD and do a clean install...

So I had to restart my PC press "F8" on startup. I still had to select which HDD to boot to, but this then took me to the repair screen and I was able to rollback to Windows 7 from t here. I hope this helps and my wireless USB was working again for all of this.