YoloMouse was the cause of the issue on the machine I was having this issue on. Thank You for your post. The wording made me think to try without it. The weird thing about this whole issue is we had a R9 380 in this computer and dropped a Gigabyte RX 580 8G in it and then the problem started... Never had an issue with the old card installed with the driver it was using.
Yeah... I think there is an OS level call, in Windows 10, that is causing these programs to take exclusive control of the desktop (or screen). Much the same way pressing the Windows key does. And by default it grabs modal control, unless specifically set to NOT do so. Even if, for instance, a service performs a fuction which executes an external program in the background. And although THAT executable may be set to non-interactive (no window) it still takes control, which then causes the current 'top' window to minimize.
Microsoft needs to fix this when running games at 'fullscreen'. And should block the ability for any process to take modal control of the desktop.
But here's the catch. If it's a Windows 10 telemetry issue (where the OS is reporting an update to Microsoft), then you can forget about seeing a fix. Which would also explain the silence, from MS, on this issue.
Just an assumption.