I am having the same problem - seemed to happen after I updated my phone to Denim and / or the latest 8.1 Developer update (no further updates are available). My principle issue is the inability to use Speakerphone functionality - everyone complains they cannot hear me, however when the device was original / new (pre updates) it worked flawlessly and was one of the reasons I chose this phone. I've been looking for a fix for several months now, and really am now simply fed up.
I'm pretty dissapointed at the longevity of this problem - this is supposed to be a flagship device, and seemingly MS doesn't care less about it. I've always purchased the best model available at the time of sale, and this type of thing makes it hard to recommend Windows phone to anyone, especially when you pick up a competitor device (Galaxy or Apple) and they 'just work'.
Is there any conrete way to resolve this, other than having the phone phyiscally replaced? I had a chat to support on the phone about this, and they advised it was likely a 'user issue' - the nerve! I'm a MS Partner / Engineer, sell primarily MS solutions and can tell you right now I know how to use a speakerphone ..
Really quite unimpressed.