As I wrote earlier, it is likely that your machine is or has been infected by malware. You really ought to call your work IT support desk (which I assume you have, given that your McAfee Antivirus is controlled by your employer).
The System Configuration utility (msconfig.exe) is a diagnostic tool. In general, after you finish using it, you should select "Normal startup," click OK, and restart your computer.
The "Selective startup" mode is used to diagnose problems. When all 3 boxes under "Selective startup" are checked, you're in the same configuration as "Normal startup." As soon as you make a change to the configuration, one or more of those boxes will become unchecked (once you apply the change(s) by clicking OK):
- If you disable one or more services on the "Services" tab, the "Load system services" box will become unchecked
- If you disable one or more of the items on the "Startup" tab, the "Load startup items" box will become unchecked
- If you select one or more of the boot options on the "Boot" tab, the "Use original boot configuration" box will become unchecked
The purposes of the boxes under "Selective startup" is to completely undo all changes you've made on one or two of the tabs while leaving changes you made on the third tab. Selecting "Normal startup" will undo all changes on all 3 tabs.
On the "Services" tab, the "Enable all" and "Disable all" buttons will enable or disable all services that are shown in the window. The purpose of the "Hide all Microsoft services" check box is to remove these services from the list so that you don't inadvertently disable a critical system service. Most of the time when you're trying to diagnose a problem using the System Configuration utility the problem will not be caused by a Microsoft service, so there's little to be gained (and potentially much to be lost) by disabling one of the Microsoft services.
If you're only using one of the tabs (e.g., the "Services" tab), clicking OK rather than Apply is acceptable.