I have an AMD processor laptop running W7 Pro 64 with IE10 and MSE, which seems to work OK with KB2859537.
KB2859537 is a kernel update, which may expose errata (bugs) in the processor of your PC.
These are listed by the processor manufacturers and usually worked around by loading microcode when the PC starts. This modifies the behaviour of the processor to avoid the errata.
If you have problems with KB2859537, it may be worth either getting the latest BIOS for your PC from your PC or motherboard manufacturer, or trying the microcode hotfixes listed in the following KB articles:
Intel processor: http://support.microsoft.com/kb/2493989
AMD processor: http://support.microsoft.com/kb/2739143 or http://support.microsoft.com/kb/2818604