I am pretty confident that there was no infection/hijack or root kit
The system has been very stable for since built (3+ years) used daily for web design and video editing, with Kaspersky updated and run weekly let alone spybot and win defender and trustee raport for browsers for internet banking.
It all went wrong from that evening the updates came with ie10 and has been plagued with 4 missing dll files since then not allowing me to run any apps or programs windows or other software, i cant even download from the web as windows blocks it and i cant open internet options.
I have registry back ups but your colleague has informed me that the registry isnt at fault..
I have been on the phone for circa 6 hours over the last few nights with Ruhal and will be again tonight, think its going to end in a format and fresh install, luckily I have monthly backups of data.
However i will take the coaching and not use reg cleaners or spybot again and leave the system protection to win Defender and Kaspersky.