To start, this is just bizarre. I've been running Win 10 Home on my laptop for several months - no issues. Got through the November Win 10 update with minimal pain.
Then had 3 updates install on 11/21/15. KB310360, KB 310368, and KB3118754. Upon restarting I got the "MSCVP100.DLL" missing error for at least 3 programs. Researched on the web and didn't find a clean answer. I did uninstall each update, one at a time,
but the problem stayed.
Ran SFC /scannow. It didn't find a problem.
I could identify three programs that were affected.
Cyberlink PowerDVD 15
Nuance PaperPort 14 Pro
and an iTunes Daemon
Went to the Control Program and found the C++ Redistributables. The 2012 version (32 and 64 bit versions) had an option to repair (after clicking on it and choosing Change). I let it repair. That fixed the problem with PowerDVD15. It worked fine. I
forgot to note if it was the 32 or 64bit that fixed it.
I looked at iTunes and found that there was an update available (they seem to come out every month or two). Installed that and all the rest of the problems went away. Even the PaperPort program is fine.
Beats me what went on. I suppose it is the third party vendors problem, but I suspicious that it is not since everything was fine until the automatic Microsoft updates were applied.
Just FWIW.