I reported a long while back about my problem. I run 3 screens and through tweaking made the font so bad text was disappearing. At that time I reset settings to default and got back to a semi-usable state.
Currently I am running 8.1 and have updated my video driver several times so I can't say exactly what is different right now configuration wise. However, while my font are still not great they are not nearly as bad as I had initially.
I attended //build this year and there was one statement made during a keynote (that I was listening very carefully for) about 8.1 supporting different DPI per monitor on multi-monitor systems. I run 3 displays all with very different DPI so I suspect this is the primary problem that got me here. It appears to me this is not in 8.1 beta so I am very interested in seeing the RTM.