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Country Boy you should only use certain programs that do work. But you have to have an advanced knowledge of the os system you are using. For instance, say the program find a part of an registry that used to belong to a program but is shared with another , maybe say a game or your os system.
Deleted or repairing that registry with out taking further steps to prevent mishap could cause serious problems that only a clean boot can cure of even worse. the fact that you are asking about a program to use with window pro 64 tells me that you don't have the skillset to accomplish a successful optimization of you system And I would recommend using the action center and your help section for your needs. Have you ever thought that you might have a trogen that is invisible to most security programs.. I would try microsoft Malicious malware remover first and listen to these guys.