Are you sure it's not "643", which appears to be common at the moment
When you try to install an update for the .NET Framework 1.0, 1.1, 2.0, 3.0, or 3.5, you may receive Windows Update error code "0x643" or Windows Installer error code "1603"
http://support.microsoft.com/kb/923100
TaurArian [MVP] 2005-2010 - Update Services