As an addendum to the above, the RF receiving indicator on the main unit stops flashing after the very first update is completed on the main unit (30-45 minutes). Also updating the forecast manually takes about 10 minutes to show the update on the main unit. (Note: The RF receiving indicator stops flashing after the first update and doesn't flash again even if you turn off your computer and then turn it on again hours later.) I haven't had an issue with the main unit not receiving the USB RF transmitter signal and the main unit is in my living room about 25 feet away.
After you do the setup (and location) and save, does the city, time, date come up immediately on the main scree? Perhaps I'm not waiting long enough for it to do it's thing?