You're right, this does NOT seem device specific - I'm experiencing a similar problem on a different system!
Upon the bootup, my system opens the COM port for 'actual' serial communication with other MPU-based devices.
However the system sometimes pops up a COM port error message, and I see this 'microsoft serial ballpoint' from my device manager - I did tried to disable it, but it comes back.
What I found so far is, if I force to transmit '0000' to the COM port while it is booting up, the Windows will detect this 'microsoft serial ballpoint'. Haven't found any way to prevent this though..
I also tried playing with 'EWF' options which did not help.
Have you discevered any fixes that works from your experience?
Usually, disabling the Mouse works - however, it seems a bit quirky - you can not always find the Mouse in device manager to disable it, etc. Some brands of serial ports have special software to disable this - try Digi.com - seems to work. We are gradually switching to using Serial to Ethernet converters - kind of an expensive way to solve a problem, but acceptable for the industrial environment we work in.
If you have questions, you can phone me at Pacific Industrial Scale Co. Ltd. in Richmond, BC, Canada - ask for Bill - I'll be away from the office the week of Jan 16....