Thanks for the update. Looks like you have a typo you may want to correct; it is Build 22621 not Build 22521. 😉
Still no explanation from MS on why so many users are having problems with this update.
I did several updates to build 22621.232 without any issues.
I also tried using the MS official R.P. ISO 22621 and everything worked fine for me on 3 different machines. 🤷♂️
Christophe Sperandio already posted earlier that the third-party ISO 22621.232 solved his problem.