FG, I don't know what the difference would be. All my test PCs are several year old Dell desktops with Intel CPUs. I don't use virtualization or Linux, but all PCs are multi-boot 64 bit Dev channel, FWIW. I have 3 printers, two Samsung lasers and one HP multi-function laser. I don't know if any of that is relevant, but I saw you or somebody mention Brother printers - that's a brand I don't have.
I connected to the pc I have:
Samsung ML2010R
HP Photosmart B109
and both from version 21354 onwards do not work with the exact same problem described in the previous comments, last night I went back to build 21343 and as if by magic the printers started working again, the problem itself is that in the Insider Blog it is described as problem solved is actually not solved, since I'm not the only one to encounter this problem you probably see that Microsoft still has to fix the bug