Hi Jonathan,
Welcome to Microsoft Community. Yes, you can absolutely use a connected second monitor with a Microsoft Surface Studio! To connect your Surface to an external display, you can use various video inputs such as USB-C, DisplayPort (DP), HDMI, DVI, or VGA. Despite the many connector types, the method for connecting your Surface to an external monitor remains the same. Connect Surface to an external display - Microsoft Support
For more detailed information on supported resolutions and refresh rates, you can refer to the: Supported external display resolution and refresh rates for Surface - Microsoft Support
I hope this helps you set up your second monitor! If you have any other questions or need further assistance, feel free to ask.
Your Sincerely Hahn. W - MSFT | Microsoft Community Support Specialist