I've got exactly the same problem, with Adobe Lightroom 6 (perpetual) on the Surface Book 2, 15", 16Gb ram, running Windows 1903 - fully updated.
NVidia driver randomly stops working, and I need to reboot to get it working again, but if fails again after about 5mins using Lightroom.
From what I've read elsewhere about the Surface Book 2, there is a significantelectrical problem in that there is not enough voltage to power the GTX 1060 graphics card. The card is power hungry (obviously) and even when connected to mains power, the battery drains when the GTX 1060 card + NVidia driver is in use - you can check this by checking the % power remaining on the battery whilst plugged in.
I can only think that the 1903 update of Windows has increased the power drain from Windows, which is exacerbating the power issue, which is causing the crashes to happen more frequently.
I'm stuck on what to do - I can only think to send the Surface Book 2 back, and purchase a proper laptop. I don't think Microsoft will be able to fix this issue via a driver or software update.